Download e-book for iPad: Aging Research in Yeast: 57 (Subcellular Biochemistry) by Michael Breitenbach,S. Michal Jazwinski,Peter Laun

By Michael Breitenbach,S. Michal Jazwinski,Peter Laun

ISBN-10: 9400725604

ISBN-13: 9789400725607

ISBN-10: 9400794207

ISBN-13: 9789400794207

This quantity comprises contributions by way of the top specialists within the box of yeast getting older. Budding yeast (Saccharomyces cerevisiae) and different fungal organisms offer versions for getting older study which are proper to organismic getting older and to the getting older approaches taking place within the human physique. Replicative getting older, during which purely the mum telephone a while whereas the daughter mobilephone resets the clock to 0 is a version for the getting older of stem mobilephone populations in people, whereas chronological getting older (measured by way of survival in desk bound part) is a version for the getting older techniques in postmitotic cells (for example, neurons of the brain). such a lot mechanisms of getting older are studied in yeast. between them, this booklet discusses: mitochondrial theories of getting older, emphasizing oxidative tension and retrograde responses; the position of autophagy and mitophagy; the connection of apoptosis to getting older strategies; the function of uneven segregation of wear in replicative getting older; the function of replication pressure; and the function of the cytoskeleton in getting older. smooth equipment of yeast genetics and genomics are defined that may be used to look for aging-specific services in a genome-wide impartial style. The similarities within the pathology of senescence (studied in yeast) and of melanoma cells, together with genome instability, are examined.

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Aging Research in Yeast: 57 (Subcellular Biochemistry) by Michael Breitenbach,S. Michal Jazwinski,Peter Laun


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